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February 9, 2011 / zzirf

Aspergers, XMRV and Beethoven

Ludwig van Beethoven : cytomegalovirus-mediated hearing loss

Submitted by Someone with Asperger’s & CFS/ME says on February 18, 2010 – 9:22am as a comment to the above link

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In his book “Genesis of Artistic Creativity: Asperger’s Syndrome and the Arts”, by Professor Michael Fitzgerald,
Ludwig van Beethoven (1770-1827) is considered to have had Asperger Syndrome.

Asperger Syndrome is an autism spectrum disorder.

40% of those with autism may show evidence of XMRV infection.

XMRV is a retrovirus, and HHV-6A is a human herpesvirus, and the two are partners in crime as far as co-infection in blood cells is concerned. HHV-6A has a preference for infecting a certain type of white blood cells, called lymphocytes : a preference for infection not in T-cells, but in B-cells, especially immature B-cells and immature astrocytes in the spinal cord and the brainstem. XMRV is being accompanied there in those lymphocytic pre-B-cells by HHV-6A, because the two of them together are partners in crime.

XMRV is a retrovirus, and cytomegalovirus is a human herpesvirus, and the two are partners in crime as far as co-infection of blood cells is concerned.

Cytomegalovirus and HHV-6A have very much in common. They share a common evolutionary origin. Both HHV-6A and CMV are the main actors in the interplay between XMRV and the human herpesviruses.

XMRV/HHV-6A/CMV is a reigning triumvirat in the spinal cord and the brainstem : The Hellish Trinity of the Spinal Cord and the Brainstem.

This Hellish Trinity, with XMRV and Cytomegalovirus as the main actors, was responsible for causing all the trouble in Beethoven’s life, which left him with complete hearing loss, or deafness : Beethoven suffered from development of cytomegalovirus-mediated hearing loss, which lead him to depression and alcohol abuse, resulting in alcoholic cirrhosis of the liver, all due to a quadruple coinfection with XMRV/HHV-6A/CMV/HCV, and he eventually may have died due to CMV peritonitis and/or CMV myocarditis and/or CMV hepatitis : XMRV-induced CMV myocarditis and/or XMRV-induced CMV peritonitis, and/or XMRV-induced CMV hepatitis.

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Literature

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XMRV in about 40% of ASD children

http://scienceblogs.com/erv/2010/01/xmrv_and_chronic_fatigue_syndr_7.php

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Development of cytomegalovirus-mediated sensorineural hearing loss

www.ncbi.nlm.nih.gov/pubmed/20083778

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BEETHOVEN : Loss of Hearing

http://www.beethoven.ws/loss_of_hearing.html

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Professor Michael Fitzgerald – Books

Genesis of Artistic Creativity: Asperger’s Syndrome and the Arts. Prof. Michael Fitzgerald.

www.professormichaelfitzgerald.eu/books.html

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Asperger’s Syndrome and … Ludwig van Beethoven (1770-1827). …

http://www.jkp.com/catalogue/book/9781843103349/contents/

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CMV myocarditis

gateway.nlm.nih.gov/MeetingAbstracts/102217234.html

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Replicative multivirus infection with cytomegalovirus, … and parvovirus B19, and latent Epstein–Barr virus infection …

www.journals.elsevierhealth.com/periodicals/jcv/article/…/abstract

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… parvovirus B19 … B19 PRCA … chronic fatigue syndrome and acute myocarditis …

linkinghub.elsevier.com/retrieve/pii/S1568997204002150

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PARVOVIRUS B19 IN HUMAN DISEASE

by KE Brown – 2003 – Cited by 96

Persistent B19 infection leading to pure red cell aplasia (PRCA) … In rare cases, B19 infection has been associated with vasculitis (20), myocarditis, …

arjournals.annualreviews.org › Journal Home › Table of Contents

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Late onset of autoimmune hemolytic anemia and pure red cell … B-cells … PRCA …. Red cell aplasia due to parvovirus b19 …

doi.wiley.com/10.1002/ajh.21086

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3 Comments

Leave a Comment
  1. Malcolm Gavin Gallegos / Feb 14 2011 1:59 PM

    I am not sure where you are getting your information, but good topic. I needs to spend some time learning more or understanding more. Thanks for magnificent information I was looking for this info for my mission.

  2. brad / Jun 8 2011 9:13 AM

    where on earth did u make the leap from beethoven’s supposed condition and XMRV/CMV/HHV6a!?

    i do agree that retroviruses are at play in a whole bunch of diseases though…

    • zzirf / Jun 17 2011 7:29 PM

      It was a leap of faith written by someone other than me but I thought it was interesting assuming that there is some truth to it. If not, then I posted a copy of it in my blog for nothing. It grabbed my attention and it must have grabbed yours too.

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